Clinical Research and Training:
Fellowship, Pulmonary and Critical Care, Massachusettes General Hospital
Research Fellowship, Pathology, Harvard University
Residency, Internal Medicine, UCLA SFVP

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Areas of Interest

• Cyclooxygenase-dependent regulation of malignant phenotypes in non-small cell lung cancer
• Development of targeted therapies for lung cancer
• Lung cancer chemoprevention and early detection
• Lung cancer immunology and tumor-mediated immune suppression

Sharma S, Stolina M, Lin Y, Gardner B, Miller PW, Kronenberg M, Dubinett SM. T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function. Journal of Immunology 1999; 163: 5020-5028.

Miller PW, Sharma S, Stolina M, Butterfield L, Luo J, Lin Y, Dohadwala M, Batra RK, Wu L, Economou JS, Dubinett SM. Intratumoral administration of adenoviral interleukin-7 gene-modified dendritic cells augments specific antitumor immunity and tumor eradication. Human Gene Therapy 2000; 11: 53-65.

Stolina M, Sharma S, Lin Y, Dohadwala M, Gardner B, Luo J, Zhu L, Kronenberg M, Miller PW, Lee J, Dubinett SM. Specific inhibition of cyclooxygenase 2 restores antitumor immunity by altering the balance of IL-10 and IL-12 synthesis. Journal of Immunology 2000; 164: 361-70.

Sharma S, Stolina M, Luo J, Strieter RM, Burdick M, Zhu LX, Batra RK, Dubinett SM. SLC/6Ckine mediates T cell-dependent antitumor responses in vivo. Journal of Immunology 2000, 164: 4558-4563.

Dohadwala M, Luo J, Zhu L, Lin Y, Dougherty GJ, Sharma S, Huang M, Põld M, Batra RK, Dubinett SM. Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44. Journal of Biological Chemistry 2001, 276: 20809-20812.

Sharma S, Stolina M, Zhu L, Lin Y, Batra R, Huang M, Strieter R, Dubinett SM SLC reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Cancer Research 2001, 61: 6406-6412.

Huang M, Batra RK, Kogai T, Lin YQ, Hershman JM, Lichtenstein A, Sharma S, Zhu LX, Brent GA, Dubinett SM. Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer. Cancer Gene Therapy 2001, 8: 612-618.

Huang M, Sharma S, Zhu LX, Luo J, Keane MP, Burdick MD, Lin YQ, Dohadwala M, Batra RK, Strieter RM, Dubinett SM. Interleukin-7 inhibits both TGF-beta production and signaling in pulmonary fibrosis fibroblasts. Journal of Clinical Investigation 2002, 109: 931-937.

Dohadwala M, Batra RK, Luo J, Lin Y, Krysan K, Põld M, Sharma S, Dubinett SM. Autocrine/Paracrine PGE2 production by NSCLC cells regulates MMP-2 and CD44 in COX-2-dependent invasion. Journal of Biological Chemistry 2002, 277:50828-50833.

Batra R, Lin Y, Gardner B, Luo J, Dohadwala M, Sharma S, Dubinett SM. Non-small cell lung cancer-derived soluble mediators enhance apoptosis in T lymphocytes through an I kappa B kinase-dependent mechanism. Cancer Research 2003, 63: 642-646.

Heuze-Vourc'h N, Zhu L, Krysan K, Batra RK, Sharma S, Dubinett SM Abnormal
IL-10Ralpha expression contributes to the maintenance of elevated COX-2 in non-small cell
lung cancer cells. Cancer Research 2003, 63: 766-770.

Sharma S, Stolina M, Baratelli F, Lin JF, Zhu L, Lin Y, Batra RK, Huang M, Dohadwala M, Dubinett SM. Tumor COX-2-dependent regulation of murine dendritic cell function. Clinical Cancer Research 2003, 9:961-968.

Zhu LX, Sharma S, Gardner B, Escuadro B, Atianzar K, Tashkin D, Dubinett SM. IL-10 mediates the sigma receptor-dependent suppression of antitumor immunity.
Journal of Immunology 2003, 170:3585-3591.

Zhang L, Sharma S, Zhu LX, Kogai T, Hershman JM, Brent GA, Dubinett SM, Huang M. Non-radioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells. Cancer Research. 2003, 63:5065-5072

Gardner B, Zhu L, Sharma S, Tashkin DP, Dubinett SM. Methanandamide increases COX-2 expression and tumor growth in murine lung cancer. FASEB Journal 2003, Nov;17(14):2157-9.

Sharma S, Batra RK, Yang SC, Hillinger S, Zhu L, Atianzar K, Strieter RM, Riedl K, Huang M, Dubinett SM. IL-7 Gene Modified Dendritic Cells Reduce Pulmonary Tumor Burden in Spontaneous Murine Bronchoalveolar Cell Carcinoma. Human Gene Therapy 2003, 14:1511-24

Riedl K, Baratelli F, Batra R, Yang SC, Luo J, Escuadro B, Figlin R, Strieter R, Sharma S, Dubinett SM. Overexpression of CCL-21/Secondary Lymphoid Tissue Chemokine in Human Dendritic Cells Augments Chemotactic Activities for Lymphocytes and Antigen Presenting Cells. Molecular Cancer 2003, 2:35

Krysan K, Merchant F, Dohadwala M, Luo J, Lin Y, Zhu L, Heuze-Vourc’h N, Goodglick L, Seligson D, Pold M, Strieter R, Sharma S, Dubinett SM. COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB Journal 2003, 10.1096/fj.03-0369fje. EPUB November 4, 2003

Mao JT, Roth MD, Serio KJ, Baratelli F, Zhu L, Holmes EC, Strieter RM, Dubinett SM. Celecoxib modulates the capacity for PGE2 and IL-10 production in alveolar macrophages. Clinical Cancer Research 2003, 9:5835-5841

Dubinett SM, Sharma S, Huang M, Dohadwala M, Pold M, Mao JT Cyclooxygenase-2 in Lung Cancer. Karger Press 2003. 37:138-62.

Pold M, Zhu L, Sharma S, Burdick M, Ying L, Lee PN, Pold A, Luo J, Krysan K, Dohadwala M, Mao J, Batra RK, Strieter RM, Dubinett SM. Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines, ENA-78/CXCL5 and IL-8/CXCL8, in human non-small cell lung cancer. Cancer Research 2004, 64:1853-1860

Yang SC, Hillinger S, Riedl K, Zhang L, Zhu L, Huang M, Atianzar K, Kuo BY, Gardner B, Batra RK, Strieter RM, Dubinett SM, Sharma S. Intratumoral administration of dendritic cells overexpressing CCL21 generates systemic antitumor responses and confers tumor immunity. Clinical Cancer Research 2004, 10:2891-2901

Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E, Strieter RM, Dubinett SM, Huang M. IL-7 and TGF-? play counter-regulatory roles in PKC-?-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. Journal of Biological Chemistry 2004, 2; 279(27):28315-9.

Pold M, Krysan K, Pold A, Dohadwala M, Heuze-Vourc’h N, Mao JT, Riedl K, Sharma S, Dubinett SM. Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small cell lung cancer. Cancer Research 2004; 64:6549-6555.

Krysan K, Dalwadi H, Sharma S, Pold M, Dubinett SM. Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. Cancer Research 2004; 64:6359-6362.

Baratelli F, Heuze-Vourc’h N, Krysan K, Dohadwala M, Riedl K, Sharma S, Dubinett SM. Prostaglandin E2-Dependent Enhancement of Tissue Inhibitors of Metalloproteinases-1 Production Limits Dendritic Cell Migration through Extracellular Matrix. Journal of Immunology 2004, 173:5458-5466.

Mao JT, Tsu IH, Dubinett SM, Adams B, Sarafian T, Baratelli F, Roth MD, Serio KJ. Modulation of Pulmonary Leukotriene B? Production by Cyclooygenase-2 Inhibitors and Lipopolysaccharide. Clinical Cancer Research 2004, 10:6872-6878.

Sharma S, Yang SC, Zhu L, Reckamp K, Gardner B, Baratelli F, Huang M, Batra RK, Dubinett SM. Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. Cancer Research 2005; 65(12):5211-20.

Baratelli F, Krysan K, Heuze-Vourc’h N, Zhu L, Escuadro B, Sharma S, Reckamp K, Dohadwala M, Dubinett SM. PGE2 confers survivin-dependent apoptosis resistance in human monocyte-derived dendritic cells. Journal of Leukocyte Biology 2005; June 9 [Epub ahead of print]

Heuze-Vourc’h N, Liu M, Dalwadi H, Baratelli FE, Zhu L, Goodglick L, Pold M, Sharma S, Ramirez RD, Shay JW, Minna JD, Strieter RM, Dubinett SM. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Biochem Biophys Res Commun 2005; 333(2):470-5.

Sharma S, Zhu L, Hillinger S, Yang SC, Atianzar K, Gardner B, Kuo B, Riedl K, Strieter RM, Batra RK, Huang M, Dubinett SM. COX-2 inhibition promotes IFN?-dependent enhancement of anti-tumor immunity. Journal of Immunology 2005; 175(2):813-9.

Krysan K, Reckamp K, Dalwadi H, Sharma S, Rozengurt E, Dohadwala M, Dubinett S. PGE2 activates MAPK/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an EGF receptor-independent manner. Cancer Research 2005; 65(14):6275-6281.

Baratelli F, Lin Y, Zhu L, Yang SC, Hueze-Vourch N, Zeng G, Reckamp K, Dohadwala M, Sharma S, Dubinett SM. PGE2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J Immunol. 2005; 175: 1483–1490.

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