Tomas Ganz, Ph.D., M.D.
Professor of Medicine and Pathology
Director, Will Rogers Pulmonary Research Laboratory
Co-Director, Center for Iron Disorders

Address:
Division of Pulmonary and Critical Care Medicine
David Geffen School of Medicine at UCLA
37-055 Center for Health Sciences
10833 Le Conte Avenue
Los Angeles, CA 90095-1690

Phone:
Office: 310-825-6112
Lab: 310-825-7499

FAX: 310-206-8766

Email:

tganz@mednet.ucla.edu
tganz@ucla.edu

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Education and Training:

Education:
Ph.D, California Institute of Technology
M.D., University of California, Los Angeles

Clinical Research and Training:
Fellowship, Pulmonary and Critical Care, University of California, Los Angeles
Residency, Internal Medicine, University of California, Los Angeles


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Areas of Interest

  • the interface between innate immunity and iron metabolism
  • innate mucosal host defense
  • antimicrobial peptides of phagocytes and epithelia
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Representative Publications:

E. V. Valore, C. H. Park, A. J. Quayle, K. R. Wiles, P. B. McCray, and T. Ganz. Human beta-defensin-1: An antimicrobial peptide of urogenital tissues. J Clin Invest 101:1633-1642, 1998.

Park, C. H., E. V. Valore, A. J. Waring, and T. Ganz. Hepcidin: a urinary antimicrobial peptide synthesized in the liver. J.Biol.Chem. 276:7806-7810, 2001

Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK and Ganz T. Interleukin-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron-regulatory hormone hepcidin. J. Clin. Invest. 113:1271-1276, 2004

Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 306:2090-3, 2004.

Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood 105:1797-802, 2004


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University of California at Los Angeles