Ganz, Ph.D., M.D.
|Professor of Medicine and Pathology
Director, Will Rogers Pulmonary Research Laboratory
Co-Director, Center for Iron Disorders
Division of Pulmonary and Critical
David Geffen School of Medicine
37-055 Center for Health Sciences
10833 Le Conte Avenue
Los Angeles, CA 90095-1690
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California Institute of Technology
M.D., University of California, Los Angeles
Research and Training:
Fellowship, Pulmonary and Critical Care, University
of California, Los Angeles
Residency, Internal Medicine, University of
California, Los Angeles
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interface between innate immunity and iron
mucosal host defense
peptides of phagocytes and epithelia
E. V. Valore, C. H. Park, A. J. Quayle, K. R.
Wiles, P. B. McCray, and T. Ganz. Human beta-defensin-1:
An antimicrobial peptide of urogenital tissues.
J Clin Invest 101:1633-1642, 1998.
Park, C. H., E. V. Valore, A. J. Waring, and T. Ganz. Hepcidin: a urinary antimicrobial peptide synthesized in the liver. J.Biol.Chem. 276:7806-7810, 2001
E, Rivera S, Gabayan V, Keller C, Taudorf
S, Pedersen BK and Ganz T. Interleukin-6 mediates
hypoferremia of inflammation by inducing the
synthesis of the iron-regulatory hormone hepcidin.
J. Clin. Invest. 113:1271-1276, 2004
Nemeth E, Tuttle MS, Powelson J, Vaughn MB,
Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin
regulates cellular iron efflux by binding
to ferroportin and inducing its internalization.
Science. 306:2090-3, 2004.
Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen
OE, Ganz T. Hepcidin excess induces the sequestration
of iron and exacerbates tumor-associated anemia.
Blood 105:1797-802, 2004
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of California at Los Angeles