Education
and Training:
Education:
Ph.D,
California Institute of Technology
M.D., University of California, Los Angeles
Clinical
Research and Training:
Fellowship, Pulmonary and Critical Care, University
of California, Los Angeles
Residency, Internal Medicine, University of
California, Los Angeles
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Representative
Publications:
E. V. Valore, C. H. Park, A. J. Quayle, K. R.
Wiles, P. B. McCray, and T. Ganz. Human beta-defensin-1:
An antimicrobial peptide of urogenital tissues.
J Clin Invest 101:1633-1642, 1998. J.
Shi, G. Zhang, H. Wu, C. Ross, F. Blecha,
and T. Ganz. Porcine epithelial beta-defensin
1 is expressed in the dorsal tongue at antimicrobial
concentrations. Infect.Immun. 67:3121-3127,
1999.
A.
M. Cole, J. Shi, A. Ceccarelli, Y. H. Kim,
A. Park, and T. Ganz. Inhibition of neutrophil
elastase prevents cathelicidin activation
and impairs clearance of bacteria from wounds.
Blood 97:297-304, 2001
T.
Ganz. Defensins and host defense. Science
286 (5439):420-421, 1999
Nemeth
E, Rivera S, Gabayan V, Keller C, Taudorf
S, Pedersen BK and Ganz T. Interleukin-6 mediates
hypoferremia of inflammation by inducing the
synthesis of the iron-regulatory hormone hepcidin.
J. Clin. Invest. 113:1271-1276, 2004
Nemeth E, Tuttle MS, Powelson J, Vaughn MB,
Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin
regulates cellular iron efflux by binding
to ferroportin and inducing its internalization.
Science. 306:2090-3, 2004.
Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen
OE, Ganz T. Hepcidin excess induces the sequestration
of iron and exacerbates tumor-associated anemia.
Blood 105:1797-802, 2004
Sorensen OE, Thapa DR, Rosenthal A, Liu L,
Roberts AA, Ganz T. Differential regulation
of beta-defensin expression in human skin
by microbial stimuli. J Immunol. 174:4870-9,
2005.
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