Michael D. Roth, M.D.
Professor of Medicine
Director, Department of Medicine Clinical Trials Research Compliance
Member, Inter-departmental Graduate Program in Toxicology

Address:
Division of Pulmonary and Critical Care Medicine
David Geffen School of Medicine at UCLA
37-131 Center for Health Sciences
10833 Le Conte Avenue
Los Angeles, CA 90095-1690

 Phone:
Lung Center Messages: 310-206-7858
Prescription Refills: 310-206-0863
Appointments: 310-825-8061

Academic Office: 310-206-7389
Research Laboratory: 310-825-9393
Emergency: 310-825-6301 (UCLA page operator)
FAX: 310-267-2020

Email:
mroth@mednet.ucla.edu

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Education and Training:

Education:
M.D., University of California, Los Angeles
B.S., University of California, Irvine

Clinical Research and Training:
Fellowship, Pulmonary and Critical Care, University of California, Los Angeles
Residency, Internal Medicine, University of California, Los Angeles
American Board of Internal Medicine, Internal Medicine - 9/86
American Board of Internal Medicine, Pulmonary Disease - 11/88
American Board of Internal Medicine, Critical Care - 11/89

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Areas of Interest

  • Immune therapy for cancer (basic research and clinical trials)
  • Gene therapy for cancer (basic research and clinical trials)
  • Dendritic cells and cytokines (basic research and clinical trials)
  • Effects of marijuana, cocaine, and tobacco on the lung, immune system, and HIV (basic and clinical research)
  • Scleroderma lung disease (clinical trials)
  • New treatments for emphysema using vitamin-A derivatives (clinical trials)
  • Bronchoscopy for the diagnosis of cancer and lung diseases (patient care and clinical trials)
  • Cough, Emphysema, Asthma, and Interstitial lung disease (patient care)
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Representative Publications:

Chao C, Jacobson LP, Jenkins FJ, Tashkin D, Martínez-Maza O, Roth MD, Ng L, Margolick JB, Chmiel JS, Zhang ZF, Detels R. Recreational Drug Use and Risk of Kaposi’s Sarcoma in HIV and HHV-8 Co-infected Homosexual Men. AIDS Research and Human Retroviruses, 25(2):149-56, 2009.

Sarafian T, Montes C, Harui A, Beedanagari SR, Kiertscher S, Stripecke R, Hossepian D, Kitchen C, Kern R, Belperio J, Roth MD. Clarifying CB2 Receptor-Dependent and Independent Effects of THC on Human Lung Epithelial Cells. Toxicol Appl Pharmacol. 15;231(3):282-90, 2008.

Muindi JR, Roth MD, Wise RA, Connett JE, O’Connor GT, Ramsdell JW, Schluger NW, Romkes M, Branch RA, Sciurba FC, for the FORTE Study Investigators. Pharmacokinetics and Metabolism of All-trans- and 13-cis-Retinoic Acid in Pulmonary Emphysema Patients. J Clin Pharm, 48(1):96-107, 2008.

Strange C, Bolster MB, Roth MD, Silver RM, Theodore A, Goldin J, Clements P, Chung J, Elashoff RM, Suh R, Smith EA, Furst DE, Tashkin DP and the Scleroderma Lung Study Research Group. Bronchoalveolar Lavage and Response to Cyclophosphamide in Scleroderma Interstitial Lung Disease. Am J Respir Crit Care Med, 177(1):91-98, 2008.

Roth MD, Connett JE, D’Armiento JM, Foronjy RF, Friedman PJ, Goldin JG, Louis TA, Mao JT, Muindi JR, O'Connor GT, Ramsdell JW, Ries AL, Scharf SM, Schluger NW, Sciurba FC, Skeans MA, Walter RE, Wendt CH, Wise RA, for the FORTE Study Investigators. Feasibililty of Retinoids For The Treatment Of Emphysema (FORTE) Study. Chest. 139:1334-1345, 2006.

Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst D, Arriola E, Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VH, Varga J, Schraufnagel D, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M for the Scleroderma Lung Study Research Group. Cyclophosphamide versus Placebo in Scleroderma Lung Disease. New Eng J Med, 354(25):11-22, 2006.

Sarafian TA, Habib N, Oldham M, Seeram N, Lee R-P, Tashkin DP, Roth MD. Inhaled Marijuana Smoke Disrupts Mitochondrial Energetics in Lung Epithelial Cells in vivo. Am J Physiol Lung Cell Mol Physiol. 290(6):L1202- L1209, 2006.

Mao JT, Fishbein MC, Adams B, Roth MD, Goodglick L, Burdick ME, Strieter RM, Holmes C, Tashkin DP, Dubinett SM. Celecoxib decreases KI-67 proliferative index in active smokers. Clin Cancer Res. 12(01):314-320, 2006.

Roth MD, Whittaker KM, Tashkin DP and Baldwin GC. Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors and the HPA axis in the huPBL-SCID model. J. Leukoc. Biol. 78(6):1198-1203, 2005.

Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, Lin J-W, Chute DJ, Mischel PS, Cloughesy TF, Roth MD. Dendritic Cell Vaccination in Glioblastoma Patients Induces Differential Systemic and Intracranial T-cell Responses Modulated by the Local Central Nervous System Tumor Microenvironment. Clin Cancer Res. 11:5515-5525, 2005.

Harui A, Roth MD, Kiertscher SM, Mitani K, Basak SK. Vaccination with helper dependent adenovirus enhances the generation of transgene-specific CTL. Gene Ther. 11(22):1617-26. 2004. Mao JT, Tashkin DP, Belloni PN, Baileyhealy I, Baratelli F, Roth MD. All Trans-retinoic Acid Modulates the Balance of MMP-9 and TIMP-1 in Patients with Emphysema. Chest. 124(5):1724-1732. 2003.

Shay A, Choi R, Whittaker K, Salehi K, Tashkin DP, Roth MD, Baldwin GC. Impairment of Antimicrobial Activity and Nitric Oxide Production in Alveolar Macrophages from Smokers of Marijuana and Cocaine. J Infect Dis. 187(4):700-704. 2003.

Yuan M, Kiertscher SM, Cheng Q, Zoumalan R, Tashkin DP, Roth MD. ?9-Tetrahydrocannabinol Regulates Th1/Th2 Cytokine Balance in Activated Human T-Cells. J. Neuroimmunol. 133(1-2):124-131. 2002.

Roth MD, Cheng Q, Harui A, Basak SK, Mitani K, Low TA, SM Kiertscher. Helper-Dependent Adenoviral Vectors Efficiently Express Transgenes in Human Dendritic Cells but Still Stimulate Antiviral Immune Responses. J Immunol. 169:4651-4656. 2002.

Basak SK, Harui A, Stolina M, Sharma S, Mitani K, Dubinett S, Roth MD. Increased Dendritic Cell Number and Function Following Continuous in vivo Infusion of GM-CSF and IL-4. Blood. 99(8):2869-2879. 2002.

Mao JT, Goldin JG, Dermand J, Ibrahim G., Brown MS, Emerick A, McNitt-Gray MF, Gjertson DW, Estrada F, Tashkin DP, Roth MD. A Pilot Study of All-Trans Retinoic Acid for the Treatment of Human Emphysema. Am J Respir Crit Care Med. 165(5):718-723. 2002.

Roth MD, Tashkin DP, Choi R, Jamieson BD, Zack JA, Baldwin GC. Cocaine Enhances Human Immunodeficiency Virus Replication in a Model of Severe Combined Immunodeficient Mice Implanted with Human Peripheral Blood Leukocytes. J Infect Dis. 185(5):701-705. 2002.

Roth MD, Marquez-Magallanes JA, Yuan M, Sun W, Tashkin DP, Hankinson O. Induction and Regulation of the Carcinogen-Metabolizing Enzyme, CYP1A1, by Marijuana Smoke and ?9-Tetrahydrocannabinol. Am J Respir Cell Mol Biol. 24(3):330-344. 2001.

Godowski PJ, Roth MD, Modlin RL. Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, but Not IL-10. J. Immunol. 165:3804-3810. 2000.

Roth MD, Gitlitz BJ, Kiertscher SM, Park AN, Mendenhall M, Moldawer N, Figlin RA. Granulocyte/Macrophage-Colony Stimulating Factor and Interleukin-4 Enhance the Number and Antigen-Presenting Activity of Circulating CD14+ and CD83+ Cells in Cancer Patients. Cancer Res. 60(7):1934-1941. 2000.

Kiertscher SM, Lou J, Dubinett SM, Roth MD. Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells. J Immunol. 164:1269-1276. 2000.

Sarafian TA, Marques JA, Shau H, Tashkin DP, Roth MD. Oxidative Stress Produced by Marijuana Smoke - An Adverse Effect Enhanced by Cannabinoids. Am J Respir Cell Mol Biol. 20:1286-1293. 1999.

Kitchen S, Korin Y, Roth MD, Landay A, Zack JA. Costimulation of Naive CD8+ Lymphocytes Induces CD4 Expression and Allows HIV-1 Infection. J Virol. 72(11):9054-9060. 1998.

Barsky SH, Roth MD, Kleerup EC, Simmons M, Tashkin DP. Histopathologic and Molecular Alterations in Bronchial Epithelium in Habitual Smokers of Marijuana, Cocaine, and/or Tobacco. J Natl Cancer Inst. 90(16): 1198-1205. 1998.

Roth MD, Arora A, Barsky SH, Kleerup EC, Simmons M, Tashkin DP. Airway Inflammation in Young Marijuana and Tobacco Smokers. Am J Respir Crit Care Med. 157(3): 928-937. 1998.

Arthur JF, Butterfield LH, Kiertscher SM, Roth MD, Bui LA, Lau R, Dubinett S, Glaspy J, Economou JS. A Comparison of Gene Transfer Methods in Human Dendritic Cells. Cancer Gene Ther. 4:17 25. 1997.

Kiertscher SM and Roth MD. Human CD14+ Leukocytes Acquire the Phenotype and Function of Antigen-Presenting Dendritic Cells when Cultured in GM-CSF and IL-4. J Leukoc Biol. 59:208-218. 1996.

Roth MD. Interleukin-2 Induces the Expression of CD45RO and the Memory Phenotype by CD45RA+ Peripheral Blood Lymphocytes. J Exp Med. 179:857-864. 1994.

Roth MD and Golub SH. Human Pulmonary Macrophages Utilize Prostaglandins and Transforming Growth Factor Beta-1 to Supress Lymphocyte Activation. J Leukoc Biol. 53:366-371. 1993.

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