UCLA - Division of Pulmonary & Critical Care Medicine

Michael D. Roth, M.D.
Professor of Medicine Member, Inter-departmental Graduate Program in Toxicology
Address: Division of Pulmonary and Critical Care Medicine David Geffen School of Medicine at UCLA 37-131 Center for Health Sciences 10833 Le Conte Avenue Los Angeles, CA 90095-1690	Phone: Lung Center Messages: 310-206-7858 Prescription Refills: 310-206-0863 Appointments: 310-825-8061 Academic Office: 310-206-7389 Research Laboratory: 310-825-9393 Emergency: 310-825-6301 (UCLA page operator) FAX: 310-267-2020 Email: mroth@mednet.ucla.edu

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Education and Training:

Education:
M.D., University of California, Los Angeles
B.S., University of California, Irvine

Clinical Research and Training:
Fellowship, Pulmonary and Critical Care, University of California, Los Angeles
Residency, Internal Medicine, University of California, Los Angeles
American Board of Internal Medicine, Internal Medicine - 9/86
American Board of Internal Medicine, Pulmonary Disease - 11/88
American Board of Internal Medicine, Critical Care - 11/89

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Areas of Interest

Immune therapy for cancer (basic research and clinical trials)
Gene therapy for cancer (basic research and clinical trials)
Dendritic cells and cytokines (basic research and clinical trials)
Effects of marijuana, cocaine, and tobacco on the lung and immune system (basic and clinical research)
Scleroderma lung disease (clinical trials)
New treatments for emphysema using vitamin-A derivatives (clinical trials)
Bronchoscopy for the diagnosis of cancer and lung diseases (patient care and clinical trials)
Cough, Asthma, and Interstitial lung disease (patient care)

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Representative Publications:

Shay A., R. Choi, K. Whittaker, K. Salehi, D.P. Tashkin, M.D. Roth, and G.C. Baldwin. Antimicrobial Activity and Nitric Oxide Production are Impaired in Alveolar Macrophages from Marijuana and Cocaine Smokers. J. Infect. Dis. in press, 2003.

T. A. Sarafian, S. Kouyoumjian, F. Khoshaghideh, D.P. Tashkin and M.D. Roth. D9-Tetrahydrocannabinol Disrupts Mitochondrial Function and Cell Energetics. Am. J. Physiol, Lung Cell Molec Physiol., in press 2003.

Roth, MD., Cheng Q., Harui A., Basak S.K., Mitani K., Low T.A., and S.M. Kiertscher. Helper-Dependent Adenoviral Vectors Efficiently Express Transgenes in Human Dendritic Cells but Still Stimulate Antiviral Immune Responses. J. Immunol. 169:4651-4656, 2002.

Basak, S.K., Harui, A., Stolina M., S. Sharma, K. Mitani, Dubinett, S. and M.D. Roth. Increased Dendritic Cell Number and Function Following Continuous in vivo Infusion of GM-CSF and IL-4. Blood, 99(8):2869-2879. 2002.

Mao, J.T., Goldin, J.G., Dermand J., Ibrahim, G., Brown, M.S., Emerick, A., McNitt-Gray M.F., Gjertson, D.W., Estrada, F., Tashkin, D.P. and M.D. Roth. A Pilot Study of All-Trans Retinoic Acid for the Treatment of Human Emphysema. Am. J. Respir. Crit. Care Med. 165(3):718-723. 2002.

Yuan, M., S. M. Kiertscher, Q. Cheng, R. Zoumalan, D. P. Tashkin, and M.D. Roth. D9-Tetrahydrocannabinol Regulates Th1/Th2 Cytokine Balance in Activated Human T-Cells. J. Neuroimmunol. 133 (1-2):124-131, 2002.

Roth, M.D., Tashkin, D.P., Choi, R., Jamieson, B.D., Zack, J.A., and G.C. Baldwin. Cocaine Enhances Human Immunodeficiency Virus Replication in a Model of Severe Combined Immunodeficient Mice Implanted with Human Peripheral Blood Leukocytes. J. Infect. Dis. 185(5):701-705. 2002.

Roth, M.D., Marquez-Magallanes, J.A., Yuan, M., Sun, W., Tashkin, D.P., and O. Hankinson. Induction and Regulation of the Carcinogen-Metabolizing Enzyme, CYP1A1, by Marijuana Smoke and D9-Tetrahydrocannabinol. Am. J. Respir. Cell Mol. Biol. 24:1-6, 2001.

Thoma-Uszynski, S., Kiertscher, S.M., Ochoa, M.T., Bouis, D.A., Norgard, M.V., Miyake, K., Godowski, P.J, Roth, M.D., and R.L. Modlin. Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, but Not IL-10. J. Immunol, 165:3804, 2000.

Roth, M.D., B.J. Gitlitz, S.M. Kiertscher, A.N. Park, M. Mendenhall, N. Moldawer and R.A. Figlin. Granulocyte/Macrophage-Colony Stimulating Factor and Interleukin-4 Enhance the Number and Antigen-Presenting Activity of Circulating CD14+ and CD83+ Cells in Cancer Patients. Cancer Res. 60(7):1934-1941, 2000.

Kiertscher, S.M., Lou, J., Dubinett, S.M., and M.D. Roth. Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells. J. Immunol. 164: 1269-1276, 2000.

Roth, M.D., Arora, A., Barsky, S.H., Kleerup, E.C., Simmons, M and D.P. Tashkin. Airway Inflammation in Young Marijuana and Tobacco Smokers. Am J Respir Crit Care Med. 157(3): 928-937,1998.

Baldwin, G.C., Tashkin, D.P., Buckley, D.M., Park, A.N., Dubinett, S.M. and M.D. Roth. Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production. Am. J. Respir. Crit. Care Med. 156:1606-1613, 1997.

Arthur, J.F., Butterfield, L.H., Kiertscher, S.M., Roth, M.D., Bui, L.A., Lau, R., Dubinett, S., Glaspy, J., and J.S. Economou. A Comparison of Gene Transfer Methods in Human Dendritic Cells. Cancer Gene Therapy. 4:17-25, 1997.

Kiertscher, S.M. and M.D. Roth. Human CD14+ Leukocytes Acquire the Phenotype and Function of Antigen-Presenting Dendritic Cells when Cultured in GM-CSF and IL-4. J. Leuko. Biol. 59:208-218, 1996.

Roth, M.D. Interleukin-2 Induces the Expression of CD45RO and the Memory Phenotype by CD45RA+ Peripheral Blood Lymphocytes. J. Exp. Med. 179:857-864, 1994.

Roth, M.D. and S.H. Golub. Human Pulmonary Macrophages Utilize Prostaglandins and Transforming Growth Factor Beta-1 to Supress Lymphocyte Activation. J. Leuko. Biol. 53:366-371, 1993.

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