Areas of Interest:

• Pulmonary Toxicology
• Toxicity and Carcinogenicity to Tobacco and Marijuana Smoke
• Oxidative Stress
• Apoptosis
• Neurotoxicology and Antioxidant Protection
• Neurodegenerative Disease
• Metal Toxicology
• Intracerebral Hemorrhage
• Atherogenesis

Sarafian TA. Methyl mercury increases intracellular Ca2+ and inositol phosphate levels in cultured cerebellar granule neurons. J. Neurochem. 61,648-657,1993.

Zhong L, Sarafian TA, Kane DJ, Charles AC, Mah SP, Edwards RH and Bredesen DE. Bcl-2 inhibits death of central neural cells induced by multiple agents. PNAS. 90,4533-4537,1993.

Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T and Bredesen DE: Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262,1274-1277,1993.

Verity MA, Sarafian TA, Pacifici EHK, and Sevanian A: Phospholipase A2 stimulation by methyl mercury in neuron culture. J. Neurochem. 62,705-714,1994.

Sarafian TS, Vartavarian L, Kane DJ, Bredesen DE, and Verity MA: Bcl-2 expression decreases methyl mercury-induced free radical generation and cell killing in a neural cell line. Toxicol. Lett. 74,149-155,1994. Sarafian TA and Bredesen DE: Is apoptosis mediated by reactive oxygen species. Free Rad. Biol. Med. 21,1-8,1994.

Sarafian TA, Bredesen DE and Verity MA: Cellular resistance to methyl mercury. Neurotoxicol. 17,27-36, 1996.

Gardner AM, Xu F, Fady C, Sarafian T, Tu Y and Lichtenstein A: Differential regulation of tumor necrosis factor - and etoposide-induced apoptosis by anti-oxidants and bcl-2. Cell Death and Differentiation 4,487-496, 1997.

Sarafian TA, Rajper N, Grigorian B, Kim A and Shau H: Cellular antioxidant properties of human natural killer enhancing factor B. Free Radical Research 26,281-289, 1997.

Kim AT, Sarafian TA, and Shau H. Characterization of antioxidant properties of natural killer enhancing factor-B and its regulation of expression by oxidative agents. Toxicol. Appl. Pharmacol. 147,135-142, 1997.

Sarafian TA, Huang C, Kim A, de Vellis J, and Shau H: Expression of the antioxidant gene nkef in the central nervous system. Mol. Chem. Neuropathol. 34, 39-51, 1998.

Sarafian TA, Verity MA, Vinters HV, Shih C, Shi L, Ji XD, Dong L, and Shau H: Differential expression of peroxiredoxin subtypes in human brain cell types. J. Neurosci. Res. 56, 206-212, 1999.

Sarafian TA, Marques JA, Shau H, Tashkin D, and Roth MD: Oxidative stress produced by marijuana smoke - An adverse effect enhanced by cannabinoids. Am. J. Resp.Cell Mol. Biol. 20, 1286-1293, 1999.

Book Chapters

Sarafian TA and Verity MA: Selective Neuronal Vulnerability, Ed. By Glen Sipes, Charleen McQueen, and Jay Gandolfi, in Comprehensive Toxicology, V.11, 1996.

Verity MA and Sarafian TA: Mercury Toxicology, in Toxicology of Metals, 1996.

Sarafian TA: Methyllmercury-induced Generation of Free Radicals. Biological Systems, pp415-444, in Metal Ions in Biological Systems. V 36, Ed by Astrid Sigel and Helmut Sigel. Marcel Dekker, Inc. New York.

Sarafian TA: Cerebellar Granule Cells, in "Cellular and Molecular Mechanisms of Toxins". Vol. IV : Site-Selective Neurotoxicity, eds. Lester D., Johannessen J., Slikker W., and Lazarovici P. 1999 (in press).Harwood Academic Publishers, Amsterdam.

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