Donald P. Tashkin, M.D.
Emeritus Professor of Medicine
Medical Director of the Pulmonary Function Laboratory

Address:
Division of Pulmonary and Critical Care Medicine
David Geffen School of Medicine at UCLA
37-131 Center for Health Sciences
10833 Le Conte Avenue
Los Angeles, CA 90095-1690

Phone:
Lung Center Messages: 310-206-7858
Prescription Refills: 310-206-0863
Appointments: 310-825-8061
Academic Office: 310-825-3163
Emergency: 310-825-6301 (UCLA page operator)
FAX: 310-794-1998

Email:

dtashkin@mednet.ucla.edu

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Education and Training:



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Areas of Interest:

  • Effects of marijuana and crack cocaine on the lung
  • Marijuana and lung carcinogenesis
  • Early intervention (e.g., inhaled corticosteroids, smoking cessation) in COPD
  • Microelectronic monitoring of medication adherence in asthma and COPD
  • Novel pharmacologic approaches to treatment of asthma and COPD
  • HRCT and physiologic assessment of small airways involvement in asthma
  • Treatment of scleroderma lung disease
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Representative Publications:

Effects of Marijuana and Cocaine on the Lung
Barsky SH, Roth MD, Kleerup EC, Simmons M, Tashkin DP. Similar molecular alterations in bronchial epithellium are observed in habitual smokers of marijuana, cocaine and/or tobacco. J National Cancer Institute 90:1198-1204, 1998.

Roth MD, Arora A, Barsky SH, Kleerup EC, Simmons M, Tashkin DP. Visual and pathologic evidence of injury to the airways of young marijuana smokers. Am J Respir Crit Care Med 157:928-937, 1998.

Matthias P, Tashkin DP, Marques-Magallanes JA, Wilkins JN, Simmons MS. Effects of varying marijuana potency on deposition of tar and D9-THC in the lung during smoking. Pharmacol Biochem Behav 58:1045-1050, 1997.

Tashkin DP, Kleerup EC, Hoh C, Kim K-J, Webber M, Gil E. Effects of "crack" cocaine on pulmonary alveolar permeability. Chest 112:327-335, 1997.

Fligiel SEG, Roth MD, Kleerup EC, Barsky SH, Simmons MS, Tashkin DP. Tracheobronchial histopathology in habitual smokers of cocaine, marijuana and/or tobacco. Chest 112:319-326, 1997.

Marques-Magallanes JA, Koyal SN, Cooper CB, Kleerup EC, Tashkin DP. Impact of habitual cocaine smoking on the physiological response to maximum exercise. Chest 112:1008-1016, 1997.

Baldwin GC, Tashkin DP, Buckley DM, Park AN, Dubinett SM, Roth MD. Habitual smoking of marijuana and cocaine impairs alveolar macrophage function and cytokine production. J Respir Crit Care Med 156:1606-1613, 1997.

Baldwin GC, Buckley DM, Roth MD, Kleerup EC, Tashkin DP. Acute activation of circulating PMNs following in vivo administration of cocaine: A potential etiology for pulmonary injury. Chest 1997; 111:698-705.

Kleerup EC, Wong Maylene, Marques JA, Goldman MD, Tashkin MD. Acute effects of intravenous cocaine on pulmonary artery pressure and cardiac index in habitual crack users. Chest 111:30-35, 1997.

Tashkin DP, Kleerup EC, Koyal S, Marques JA, Goldman M. Acute effects of inhaled and intravenous cocaine on airway dynamics. Chest 110:904-910, 1996.

Early Intervention in COPD (the Lung Health Study)

Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA, for the Lung Health Study Research Group. Methacholine reactivity predicts changes in lung function over time in smokers with early COPD. Am J Respir Crit Care Med 153:1802-1811, 1996.

Anthonisen NR, Connett JE, Kiler JP, Altose MD, Bailer WC, Buist AS, Conway WA, Enright PA. Kanner RE, O'Hara P, Owens GR, Scanlon PD, Tashkin DP, Wise RA for the Lung Health Study Research Group. Effects of smoking intervention and the use of an anticholinergic bronchod.lator on the rate of deline in FEV1. The Lung Health Study. JAMA 272:1497-1505, 1994.

Microelectronic Monitoring of Adherence

Tashkin DP. Microelectronic Adherence Monitors for Metered-Dose Inhalers: Who Monitors the Monitors? (Editorial) J Allergy Clin Immunol 1999 104:22-24.

Simmons MS, Nides MA, Kleerup, EC, Chapman KR, Milgrom H, Rand CS, Spector SL, Tashkin DP. Validation of the DoserTM, a new device for monitoring metered-dose inhaler use. J Allergy Clin Immunol 102:409-413, 1998.

Small Airways

Goldin JG, Tashkin DP, Kleerup EC, Greaser LE, Haywood UM, Sayre JW, Simmons MD, Suttorp M, Colice GL, Vander Burgt JA, Aberle DR. Comparative effects of HFA- and CFC-beclomethasone diproprionate inhalation on small airways: assessment using functional helical thin-section computed tomography. J Allergy Clin Immunol 1999; 104:S258-267.


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