Areas of Interest - Basic Research

Miscellaneous

Sarafian: Ongoing studies in collaboration with Dr. Hungyi Shau have focused on the expression and function of peroxiredoxin, a novel antioxidant gene in the nervous system. Several subtypes of this gene are differentially expressed in cell types within the brain and other tissues and the respective functions of these gene subtypes are currently under investigation.

Collaborative studies with Nilam Mody and Dr. Linda Demer examine oxidative effects of low and high density lipoproteins on selected cells of the arterial circulatory system.

Collaborative studies with Dr. Jean de Vellis and Dr. Joel Dopp examine the role of tumor necrosis factor in oxidative stress associated with glial pathology in multiple schlerosis.

Collaborative studies with Veronic Villa and Drs. Jake Lusis and Tom Drake explore calcium dysregulation, oxidative stress, and cytopatholgy in knock-out and transgenic mice manifesting cardiovascular disorders relevant to human heart disease.

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